Welcome to HiSTaR Tutorials

HiSTaR: identifying spatial domains with Hierarchical Spatial Transcriptomics variational autoencoder

• Environment Setup and Configuration
• DLPFC Clustering Analysis
• Hunman Breast Cancer Clustering Analysis
• Mouse Brain Clustering Analysis
• Slide-SeqV2 MOB Clustering Analysis
• Stereo-Seq MOB Clustering Analysis
• STARmap Mouse visual Cortex Clustering Analysis
• Mouse Breast Cancer sections batch effect correction
• Mouse Brain sections batch effect correction
• Mouse Breast Brain Anterior-Posterior batch effect correction

Overview

in this study, we propose a Hierarchical ST variational autoencoder (HiSTaR) to extract multi-level latent features of spots. HiSTaR tends to perform well in identifying spatial domains across multiple datasets from diverse platforms, consistently showing superior results compared to existing methods.